abstract：:Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) associated with chronic rhinosinusitis (CRS) and/or asthma comprises a distinct clinical syndrome referred to as NSAIDs exacerbated respiratory disease (NERD). Patients with NERD tend to have more severe course of both upper (CRS and nasal polyps) and l...

journal_title：Current allergy and asthma reports

authors： Makowska J,Lewandowska-Polak A,Kowalski ML

更新日期：2015-08-01 00:00:00

abstract：:Oral food challenges are the gold-standard diagnostic investigation for diagnosing food allergy. They allow a subject to consume an age-appropriate portion of allergenic food under surveillance to assess whether a reproducible immune-mediated adverse response is demonstrated. The specific design of food challenge must...

journal_title：Current allergy and asthma reports

authors： Feeney M,Marrs T,Lack G,Du Toit G

更新日期：2015-08-01 00:00:00

abstract：:The incidence of immune disorders is growing parallel with practices associated with westernization, such as dietary changes, increased use of antibiotics, or elevated rates of Cesarean section. These practices can significantly impact the gut microbiota, the collection of bacteria residing in the human gastrointestin...

journal_title：Current allergy and asthma reports

authors： Shen N,Clemente JC

更新日期：2015-07-01 00:00:00

abstract：:Urticaria can present acutely and be self-limiting or become chronic and persist for weeks, months, or years. In either case, the condition may have a significant impact on the patient's quality of life. Two major consensus groups, the EAACI/WAO and the AAAAI/ACAAI Joint Task Force, have written guidelines on the diag...

journal_title：Current allergy and asthma reports

authors： Fine LM,Bernstein JA

更新日期：2015-06-01 00:00:00

abstract：:Perioperative anaphylaxis is a unique condition as a result of the additive cardiovascular effects of anesthetics on the cardiovascular disturbances of anaphylaxis. It occurs mainly in adulthood, primarily follows anesthetic induction, and for the most part, is an IgE-mediated pathomechanism. Neuromuscular blocking ag...

journal_title：Current allergy and asthma reports

authors： Dewachter P,Mouton-Faivre C,Hepner DL

更新日期：2015-05-01 00:00:00

abstract：:Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the upper airways of which two major phenotypes exist, CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP). Some patients with CRS have suboptimal response to current guideline treatments. These patients remain severe and uncontrolled b...

journal_title：Current allergy and asthma reports

authors： López-Chacón M,Mullol J,Pujols L

更新日期：2015-05-01 00:00:00

abstract：:Hypersensitivity in the allergic setting refers to immune reactions, stimulated by soluble antigens that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. As the number of known exposures associated with anaphylaxis is limited, identification of novel causative agents is important in ...

journal_title：Current allergy and asthma reports

authors： Platts-Mills TA,Schuyler AJ,Hoyt AE,Commins SP

更新日期：2015-04-01 00:00:00

abstract：:Asthma and chronic obstructive pulmonary disease (COPD) have traditionally been viewed as distinct clinical entities. Recently, however, much attention has been focused on patients with overlapping features of both asthma and COPD: those with asthma COPD overlap syndrome (ACOS). Although no universal definition criter...

journal_title：Current allergy and asthma reports

authors： Bujarski S,Parulekar AD,Sharafkhaneh A,Hanania NA

更新日期：2015-03-01 00:00:00

abstract：:Over the past few decades, significant scientific progress has influenced clinical allergy practice. The biological standardization of extracts was followed by the massive identification and characterization of new allergens and their progressive use as diagnostic tools including allergen micro arrays that facilitate ...

journal_title：Current allergy and asthma reports

authors： Barber D,Díaz-Perales A,Villalba M,Chivato T

更新日期：2015-02-01 00:00:00

abstract：:Occupational asthma (OA) is a complex disease that is often hard to diagnose due to difficulties in detecting relevant exposure, along with inherent differences in disease susceptibility. Numerous studies have attempted to identify relevant biological and genetic markers for OA and to devise tools capable of detecting...

journal_title：Current allergy and asthma reports

authors： Hur GY,Park HS

更新日期：2015-01-01 00:00:00

abstract：:Sublingual immunotherapy (SLIT) is a well-established allergen-specific immunotherapy and a safe and effective strategy to reorient inappropriate immune responses in allergic patients. SLIT takes advantage of the tolerogenic environment of the oral mucosa to promote tolerance to the allergen. Several clinical studies ...

journal_title：Current allergy and asthma reports

authors： Jay DC,Nadeau KC

更新日期：2014-11-01 00:00:00

abstract：:Primary immunodeficiencies (PIDs) are a group of genetically heterogeneous disorders that present with very similar symptoms, complicating definitive diagnosis. More than 240 genes have hitherto been associated with PIDs, of which more than 30 have been identified in the last 3 years. Next generation sequencing (NGS) ...

journal_title：Current allergy and asthma reports

authors： Raje N,Soden S,Swanson D,Ciaccio CE,Kingsmore SF,Dinwiddie DL

更新日期：2014-10-01 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome (ALPS) is characterized by immune dysregulation due to a defect in lymphocyte apoptosis. The clinical manifestations may be noted in multiple family members and include lymphadenopathy, splenomegaly, increased risk of lymphoma, and autoimmune disease, which typically involves he...

journal_title：Current allergy and asthma reports

authors： Shah S,Wu E,Rao VK,Tarrant TK

更新日期：2014-09-01 00:00:00

abstract：:Given the increased recognition of pediatric allergic contact dermatitis and lack of patch testing consensus in children, we present a minimum basic 20-allergen North American pediatric series, for screening children ages 6-12 with suspected contact allergy. ...

journal_title：Current allergy and asthma reports

authors： Jacob SE,Admani S,Herro EM

更新日期：2014-06-01 00:00:00

abstract：:Health-related quality of life (HRQL) has become an emerging focus of interest in food allergy. Food allergy is a disease characterized by low mortality and symptoms which only occur during an allergic reaction. However, food-allergic patients continuously need to be alert when eating in order to prevent potentially s...

journal_title：Current allergy and asthma reports

authors： van der Velde JL,Dubois AE,Flokstra-de Blok BM

更新日期：2013-12-01 00:00:00

abstract：:Although the smoking prevalence in the United States continues to decline since the Surgeon General's first report in 1964, certain vulnerable populations continue to be disproportionately affected by the adverse consequences of tobacco smoke exposure. Children are particularly vulnerable to exposure and are likely to...

journal_title：Current allergy and asthma reports

authors： Ciaccio CE,Gentile D

更新日期：2013-12-01 00:00:00

abstract：:Until recently, idiopathic pulmonary fibrosis (IPF) has been a devastating and generally fatal disease with no effective therapeutic. New developments in understanding the biology of the disease include a growing consensus that the lesions are mainly composed of cells that originated from resident fibroblasts. New dev...

journal_title：Current allergy and asthma reports

authors： Gomer RH

更新日期：2013-12-01 00:00:00

abstract：:Traditionally, symptoms are important patient-oriented outcomes in asthma treatment, and assessment of symptoms is an essential component of assessing asthma control. However, variable airways obstruction, airways hyperresponsiveness and chronic inflammation are key components of the asthma syndrome, and correlations ...

journal_title：Current allergy and asthma reports

authors： Nuijsink M,De Jongste JC,Pijnenburg MW

更新日期：2013-10-01 00:00:00

abstract：:Expanding knowledge about an interaction of the bacterial colonization with pathogenic and non-pathogenic bacteria and the human immune system leads to speculation on potential effects on health and disease. Recent advances in sequencing technologies and new bioinformatic possibilities now allow investigating the micr...

journal_title：Current allergy and asthma reports

authors： Bendiks M,Kopp MV

更新日期：2013-10-01 00:00:00

abstract：:Recognition of asthma as a heterogeneous disease revealed different potential molecular targets and urged the development of targeted, customized treatment modalities. Evidence was provided for different inflammatory subsets of asthma and more recently, further refined to T helper (Th)2-high and Th2-low subphenotypes ...

journal_title：Current allergy and asthma reports

authors： Diamant Z,Tufvesson E,Bjermer L

更新日期：2013-10-01 00:00:00

abstract：:The best possible allergen immunotherapy clinical outcomes require the provision of high quality and safe allergen immunotherapy extract preparations. Evolving national guidelines and regulatory bodies have devoted special attention to the safe compounding of sterile products, including allergen extracts. It is incumb...

journal_title：Current allergy and asthma reports

authors： Nelson MR,Petersen MM,Wolverton WO,Mikita CP

更新日期：2013-08-01 00:00:00

abstract：:Subcutaneous allergen immunotherapy (SCIT) is beneficial for the treatment of allergic rhinitis, asthma, and in preventing stinging insect anaphylaxis, but is not without risks. Four retrospective surveillance surveys and one on-going national prospective study have attempted to characterize the incidence and risk fac...

journal_title：Current allergy and asthma reports

authors： Kannan JA,Epstein TG

更新日期：2013-08-01 00:00:00

abstract：:The use of saline nasal irrigation (SNI) in the treatment of nasal and sinus disorders has its roots in the yoga tradition and homeopathic medicine. In recent years, SNI has been increasingly observed as concomitant therapy for acute (ARS) and chronic rhinosinusitis (CRS). Various devices are employed, such as nasal d...

journal_title：Current allergy and asthma reports

authors： Achilles N,Mösges R

更新日期：2013-04-01 00:00:00

abstract：:The dynamic expression of various phenotypic markers during B cell development not only defines the particular stage in ontogeny but also provides the necessary growth, differentiation, maturation and survival signals. When a B cell at any given stage becomes cancerous, these cell surface molecules, intracellular sign...

journal_title：Current allergy and asthma reports

authors： Baskar S,Muthusamy N

更新日期：2013-02-01 00:00:00

abstract：:Asthma is a chronic inflammatory disease of the airways characterized by structural airway changes, which are known as airway remodeling, including smooth muscle hypertrophy, goblet cell hyperplasia, subepithelial fibrosis, and angiogenesis. Vascular remodeling in asthmatic lungs results from increased angiogenesis, w...

journal_title：Current allergy and asthma reports

authors： Meyer N,Akdis CA

更新日期：2013-02-01 00:00:00

abstract：:Otitis media is one of the most common childhood infections leading to doctor's visits and a leading cause of antibiotic prescriptions in children. Twin and family studies have confirmed that the predisposition of developing a bacterial middle ear infection is genetically determined. Several case-control studies have ...

journal_title：Current allergy and asthma reports

authors： Hafrén L,Kentala E,Einarsdottir E,Kere J,Mattila PS

更新日期：2012-12-01 00:00:00

abstract：:Stem cell transplant (SCT) has long been the standard of care for several hematologic, immunodeficient, and oncologic disorders. Recently, SCT has become an increasingly utilized therapy for refractory autoimmune rheumatologic disorders (ARDs). The efficacy of SCT in ARDs has been attributed to resetting an aberrant i...

journal_title：Current allergy and asthma reports

authors： Mascarenhas S,Avalos B,Ardoin SP

更新日期：2012-12-01 00:00:00

abstract：:The activation of a T cell through T cell receptor (TCR) is fundamental to adaptive immune responses. The lymphocyte specific kinase (LCK) plays a central role in the initiation of signaling from the TCR. TCR activates LCK through the adaptor protein uncoordinated 119 (UNC119). A mutation of human UNC119 impairs LCK a...

journal_title：Current allergy and asthma reports

authors： Gorska MM,Alam R

更新日期：2012-10-01 00:00:00

abstract：:The physical urticarias are a heterogeneous subgroup of chronic urticarias in which wheals can be reproducibly induced by different specific physical stimuli such as cold, heat, pressure, vibration, or sunlight. Physical urticarias comprise up to 25 % of chronic urticarias and occur more frequently in young adults. Sy...

journal_title：Current allergy and asthma reports

authors： Abajian M,Młynek A,Maurer M

更新日期：2012-08-01 00:00:00

abstract：:The present review aims to identify and summarize epidemiologic investigations published during 2011 on the environmental risk factors for asthma. Potentially eligible papers were identified by a MEDLINE search. In total, 1,130 items were retrieved. Based on a broad definition of environment, the following topics were...

journal_title：Current allergy and asthma reports

authors： Antó JM

更新日期：2012-06-01 00:00:00

abstract：:Guillain-Barré syndrome (GBS) is a classic failure of the immune system with a life-threatening attack upon a critical self-component. The active phase of the disease is short, concordant with the latency of a primary adaptive immune response. Triggers for GBS include infection and (rarely) vaccination; cross-reactivi...

journal_title：Current allergy and asthma reports

authors： Hardy TA,Blum S,McCombe PA,Reddel SW

更新日期：2011-06-01 00:00:00

abstract：:Epinephrine can be lifesaving in episodes of anaphylaxis, yet it is underprescribed and underused. Tracking of epinephrine refills over time for patients with a diagnosis of anaphylaxis has not been reported. This study reports on the refill history of 14,677 patients in a large HMO who received an initial dispensing ...

journal_title：Current allergy and asthma reports

authors： Kaplan MS,Jung SY,Chiang ML

更新日期：2011-02-01 00:00:00

abstract：:The pathology of atopic dermatitis is orchestrated on the cellular level by several different cell types in the characteristic skin lesions. In such lesions, histamine as a mediator of many biological functions is also present in high concentrations. Most of the cells involved in the inflammatory responses express the...

journal_title：Current allergy and asthma reports

authors： Mommert S,Gschwandtner M,Gutzmer R,Werfel T

更新日期：2011-02-01 00:00:00

abstract：:Nonspecific lipid transfer proteins (LTPs) are important allergens in fruits, vegetables, nuts, pollen, and latex. Despite their wide distribution throughout the plant kingdom, their clinical relevance is largely confined to the Mediterranean area. As they can sensitize via the gastrointestinal tract, LPTs are conside...

journal_title：Current allergy and asthma reports

authors： Egger M,Hauser M,Mari A,Ferreira F,Gadermaier G

更新日期：2010-09-01 00:00:00

abstract：:Allergic conjunctivitis (AC) can be divided into the primary form (caused by an allergic reaction occurring primarily in the conjunctivae) and the secondary form (induced by allergic reaction originating primarily in the nasal mucosa, where the released mediators can reach conjunctiva through the lacrimal system, the ...

journal_title：Current allergy and asthma reports

authors： Pelikan Z

更新日期：2010-07-01 00:00:00

abstract：:Chronic rhinosinusitis (CRS) is one of the most common chronic disease conditions in the United States. Currently, diagnosis is based initially on clinical symptomatology and signs, but the final diagnosis of CRS should be confirmed by objective measures. CT of the paranasal sinuses is the most commonly obtained test ...

journal_title：Current allergy and asthma reports

authors： Bhattacharyya N

更新日期：2010-05-01 00:00:00

abstract：:Immune responses can be compartmentalized into innate versus adaptive components. This relatively recent dichotomy positioned the innate immune system at the interface between the host and the external environment and provided a new conceptual framework with which to view allergic diseases, including asthma. Airway ep...

journal_title：Current allergy and asthma reports

authors： Georas SN,Rezaee F,Lerner L,Beck L

更新日期：2010-03-01 00:00:00

abstract：:The role of distinct CD4(+) T-cell populations in regulating the nature and strength of immune responses is well documented and in the past has principally focused on the cross-regulation of T-helper type 1 (Th1) and Th2 cells, which secrete interferon-gamma and interleukin-4, respectively. However, the identification...

journal_title：Current allergy and asthma reports

authors： McGuirk P,Higgins SC,Mills KH

更新日期：2010-01-01 00:00:00

abstract：:Although eustachian tube dysfunction and bacterial infection have been shown to cause otitis media with effusion (OME), other etiologies are possible. One of the most common medical conditions in children is obesity, which can have effects throughout the body. Little is known, however, about the relationship between o...

journal_title：Current allergy and asthma reports

authors： Lee SK,Yeo SG

更新日期：2009-11-01 00:00:00

abstract：:Mouse allergen has long been recognized as an important cause of occupational allergy and asthma, but only recently has it been implicated in asthma and allergic diseases in community settings. Recent studies have established that mouse allergen is detectable in most US homes, with strikingly high levels in some inner...

journal_title：Current allergy and asthma reports

authors： Matsui EC

更新日期：2009-09-01 00:00:00